Effect of methionine synthase A2756G and methionine synthase reductase A66G gene polymorphisms in male infertility
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Abstract
Objective: In this study, we investigated whether methionine synthase (MTR) A2756G and methionine synthase reductase (MTRR) A66G gene polymorphisms were related with infertility.
Materials and methods: Blood samples of 117 infertile (66 azoospermia, 51 oligozoospermia) cases and 70 healthy men were collected and genotyped for MTR A2756G and MTRR A66G polymorphisms.
Results: In control and study groups MTR A2756G genotypes were 64% AA, 34% AG, 1% GG and 54% AA, 39% AG, 7% GG , respectively, and the frequency of the G allele in the study group was increased compared to control group (p<0.05). MTRR A66G genotypes were 9% AA, 79% AG, 13% GG in control group and 4% AA, 73% AG, 23% GG in control group without statistically significant difference (p>0.05).
Conclusion: MTR A2756G gene polymorphism may have an important effect on the evolution of male infertility. Finding of increased G allele frequency of study group will lead to further and larger sample-size studies.