TREATMENT OF CYSTINURIA WITH CAPTOPRIL: CASE REPORT

Abstract

Abstract

Cystinuria is an autosomal recessive hereditary disorder associated with urolithiasis. Cystin stones have a high recurrens rate and are generally resistant to noninvazive treatment modalities such as shock wave lithotripsy (SWL). After the surgical management of stone, the aim is to increase the urinary cystine solubility with hydration, alkalinization of urine and medications. Medical treatment alternatives available are D-penisilamine, alpha mercaptopropionylglycine (MPG) and captopril.

We report a patient whom we treated with alkalinization and captopril for 2 years. There was a marked decline in urinary cystine excretion. The stones did not recur and no adverse effects were noted.

Captopril should be considered as an alternative to in the management of cystinuria.